MYH9

Across TCGA pan-cancer cohorts, MYH9 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MYH9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MYH9 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MYH9 is over-expressed in tumor.

HNSC, PDAC, and OV are the cancer types where MYH9 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYH9 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.618	<.001	12	view →
PDAC	Female	All	+0.573	<.001	8	view →
OV	All	All	+0.332	.029	2	view →
LSCC	Female	III,IV	+0.253	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MYH9–HNSC

Open the HNSC breakdown →