MYH9

Across TCGA patient cohorts, MYH9 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MYH9-associated genes across cancer lineages are Akt_pS473, 14-3-3_epsilon, and Caveolin-1. Each is linked with MYH9 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH9-to-partner and partner-to-MYH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by MYH9-low versus MYH9-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH9→partner) and Y-score (partner→MYH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Akt_pS473 →	-0.275	-1.662	.016	.011	3	3
BRCA	14-3-3_epsilon →	+0.132	+1.594	.003	.045	3	3
COAD	Caveolin-1 →	-0.608	-1.917	.008	.004	3	3
COAD	FASN →	+0.282	+1.288	.026	.035	3	3
COAD	GAPDH →	+0.592	+1.934	<.001	.002	3	3
COAD	NF-kB-p65_pS536 →	-0.421	-1.700	.014	.038	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Akt_pS473 by MYH9 expression — BLCA

Explore this box plot interactively →