MYH9

Across TCGA cell cohorts, MYH9 mutation is significantly associated with the RNA expression of many other genes, with 1,485 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH9-associated genes across cancer lineages are LRIT1, ACTL7B, and BHLHE23. Each is linked with MYH9 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH9-to-partner and partner-to-MYH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by MYH9-low versus MYH9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH9→partner) and Y-score (partner→MYH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRIT1 →	+0.021	+3.362	<.001	.001	3	3
OESOPHAGUS	ACTL7B →	+0.018	+3.409	<.001	.005	3	2
BLOOD_Leukemia	BHLHE23 →	+0.836	+2.954	.006	.005	3	2
LARGE_INTESTINE	CCDC134 →	+0.751	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	TNRC6B →	+0.854	+2.764	<.001	<.001	3	2
LARGE_INTESTINE	ADNP2 →	+0.810	+3.130	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,485 associations by consensus.

LRIT1 by MYH9 expression — BLOOD_Leukemia

Explore this box plot interactively →