MYH9

Across TCGA cell cohorts, MYH9 mutation is significantly associated with the mutation status of many other genes, with 7,249 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH9-associated genes across cancer lineages are COL7A1, PRR12, and ADCY4. Each is linked with MYH9 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYH9-to-partner and partner-to-MYH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COL7A1 grouped by MYH9-low versus MYH9-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH9→partner) and Y-score (partner→MYH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COL7A1 →	+2.960	+3.686	<.001	<.001	1	6
SOFT_TISSUE	PRR12 →	+3.066	+4.369	.005	.005	1	6
LUNG_NSCLC_LUAD	ADCY4 →	+3.078	+2.944	.003	.003	1	6
BLOOD_Leukemia	TRRAP →	+2.960	+3.686	<.001	<.001	1	6
LARGE_INTESTINE	CACNA1H →	+2.378	+3.000	<.001	<.001	1	6
PANCREAS	CASZ1 →	+5.115	+5.115	.005	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,249 associations by consensus.

COL7A1 by MYH9 expression — BLOOD_Leukemia

Explore this box plot interactively →