Across TCGA cell cohorts, MYH6 mutation is significantly associated with the RNA expression of many other genes, with 777 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH6-associated genes across cancer lineages are SKI, ZNF66, and BHLHA15. Each is linked with MYH6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH6-to-partner and partner-to-MYH6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH6→partner) and Y-score (partner→MYH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SKI →	+0.507	+3.169	.005	.006	3	2
LARGE_INTESTINE	ZNF66 →	-0.877	-3.459	<.001	<.001	3	2
SKIN	BHLHA15 →	+0.397	+1.916	.001	.005	3	2
SKIN	ZNF563 →	-0.519	-2.459	.003	.006	3	2
LARGE_INTESTINE	CBY1 →	+0.539	+2.160	<.001	.001	3	2
LARGE_INTESTINE	FAM149A →	+1.380	+2.667	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 777 associations by consensus.

Exploration

MYH6 survival (RNA) · tumor vs normal (RNA) · all MYH6 data types