MYH4

Across TCGA patient cohorts, MYH4 mutation is significantly associated with the total protein of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH4-associated genes across cancer lineages are 4E-BP1, GAPDH, and BRCA2. Each is linked with MYH4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MYH4-to-partner and partner-to-MYH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MYH4-low versus MYH4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH4→partner) and Y-score (partner→MYH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.289	+3.584	.007	.002	3	4
COAD	GAPDH →	+0.506	+2.593	.017	.006	3	4
STAD	BRCA2 →	-0.149	-3.700	.004	.001	3	3
STAD	CD31 →	-0.159	-1.906	.005	.015	3	3
STAD	C-Raf →	+0.128	+3.700	.027	.001	2	4
UCEC	Shc_pY317 →	-0.126	-1.280	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

4E-BP1 by MYH4 expression — STAD

Explore this box plot interactively →