MYH4

Across TCGA cell cohorts, MYH4 mutation is significantly associated with the RNA expression of many other genes, with 1,102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH4-associated genes across cancer lineages are OR4A47, FAM149A, and PIMREG. Each is linked with MYH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYH4-to-partner and partner-to-MYH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A47 grouped by MYH4-low versus MYH4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH4→partner) and Y-score (partner→MYH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR4A47 →	+0.020	+5.614	<.001	.002	3	2
LARGE_INTESTINE	FAM149A →	+1.479	+3.404	<.001	<.001	3	2
LARGE_INTESTINE	PIMREG →	+0.760	+2.628	.005	.002	3	2
LARGE_INTESTINE	EDEM1 →	+0.791	+3.389	<.001	.001	3	2
LARGE_INTESTINE	TMEM268 →	+0.771	+2.628	<.001	.002	3	2
LARGE_INTESTINE	MT1E →	+3.340	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,102 associations by consensus.

OR4A47 by MYH4 expression — PANCREAS

Explore this box plot interactively →