MYH2

Across TCGA patient cohorts, MYH2 mutation is significantly associated with the RNA expression of many other genes, with 5,335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH2-associated genes across cancer lineages are C1QBP, SLC22A3, and TIPIN. Each is linked with MYH2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYH2-to-partner and partner-to-MYH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by MYH2-low versus MYH2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH2→partner) and Y-score (partner→MYH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	C1QBP →	+0.491	+1.531	<.001	.009	3	6
LUAD	SLC22A3 →	-0.823	-1.561	<.001	<.001	3	5
COAD	TIPIN →	+0.484	+2.058	<.001	<.001	3	5
STAD	CHAF1B →	+0.447	+2.634	.003	.004	3	5
UCEC	UQCRH →	+0.523	+2.032	.005	<.001	3	5
UCEC	RGN →	-0.485	-2.786	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,335 associations by consensus.

C1QBP by MYH2 expression — STAD

Explore this box plot interactively →