MYH13

Across TCGA cell cohorts, MYH13 mutation is significantly associated with the RNA expression of many other genes, with 1,654 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH13-associated genes across cancer lineages are METTL4, APTX, and LYSMD1. Each is linked with MYH13 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH13-to-partner and partner-to-MYH13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL4 grouped by MYH13-low versus MYH13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH13→partner) and Y-score (partner→MYH13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL4 →	+0.532	+1.949	.001	.002	3	3
LARGE_INTESTINE	APTX →	+0.328	+3.459	.001	.001	3	3
BLOOD_Leukemia	LYSMD1 →	+0.993	+3.228	<.001	.004	3	3
LARGE_INTESTINE	GPR182 →	+0.070	+2.643	.009	.001	3	3
LARGE_INTESTINE	NIPSNAP1 →	+0.573	+2.700	.008	.001	3	3
LARGE_INTESTINE	PAFAH1B1 →	+0.554	+2.222	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,654 associations by consensus.

METTL4 by MYH13 expression — LARGE_INTESTINE

Explore this box plot interactively →