MYH13

Across TCGA cell cohorts, MYH13 mutation is significantly associated with the mutation status of many other genes, with 6,893 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH13-associated genes across cancer lineages are SHANK1, GLI2, and THSD7B. Each is linked with MYH13 in more than 6 cancer types. Because this analysis shows association rather than direction, both MYH13-to-partner and partner-to-MYH13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHANK1 grouped by MYH13-low versus MYH13-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH13→partner) and Y-score (partner→MYH13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SHANK1 →	+3.510	+3.807	.004	.004	1	7
OVARY	GLI2 →	+2.977	+4.273	.006	.006	1	7
SOFT_TISSUE	THSD7B →	+3.192	+3.392	.002	.002	1	7
LARGE_INTESTINE	NPAP1 →	+2.156	+2.064	<.001	<.001	1	7
BLOOD_Leukemia	CACNA1I →	+2.418	+2.206	.002	.002	1	6
OESOPHAGUS	PCDH15 →	+2.400	+3.688	.007	.007	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,893 associations by consensus.

SHANK1 by MYH13 expression — BREAST

Explore this box plot interactively →