MYH10

Across TCGA patient cohorts, MYH10 mutation is significantly associated with the RNA expression of many other genes, with 6,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH10-associated genes across cancer lineages are GPI, TRAIP, and UQCR10. Each is linked with MYH10 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYH10-to-partner and partner-to-MYH10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPI grouped by MYH10-low versus MYH10-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH10→partner) and Y-score (partner→MYH10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GPI →	+0.599	+3.750	<.001	<.001	3	6
HNSC	TRAIP →	+0.571	+2.602	.002	.006	3	5
UCEC	UQCR10 →	+0.290	+2.654	<.001	<.001	3	5
STAD	FBXO7 →	+0.317	+3.492	.005	.002	3	5
STAD	CCNB2 →	+0.718	+3.016	.001	<.001	3	5
UCEC	CHAF1B →	+0.634	+1.647	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,383 associations by consensus.

GPI by MYH10 expression — STAD

Explore this box plot interactively →