MYH1

Across TCGA patient cohorts, MYH1 mutation is significantly associated with the total protein of many other genes, with 91 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH1-associated genes across cancer lineages are ATM, p38-MAPK_pT180_Y182, and GAPDH. Each is linked with MYH1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYH1-to-partner and partner-to-MYH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MYH1-low versus MYH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH1→partner) and Y-score (partner→MYH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.603	-2.187	<.001	<.001	3	6
UCEC	p38-MAPK_pT180_Y182 →	-0.250	-1.353	.031	.013	3	5
COAD	GAPDH →	+0.579	+2.915	.002	<.001	3	5
UCEC	ASNS →	+0.254	+1.064	.006	.043	3	5
COAD	Caspase-7-cleavedD198 →	+1.208	+2.476	<.001	.009	3	4
LUSC	FoxM1 →	+0.236	+1.783	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

ATM by MYH1 expression — UCEC

Explore this box plot interactively →