MYH1

Across TCGA pan-cancer cohorts, MYH1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MYH1 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MYH1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MYH1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and CHOL show a favorable association.

ACC, HNSC, and BRCA are the cancer types where MYH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.372	0.762	<.001	96	view →
HNSC	OS	Median	All	0.710	0.822	<.001	62	view →
BRCA	OS	Median	III,IV	0.652	0.435	<.001	38	view →
LUSC	OS	Tertile	III,IV	0.210	0.517	.006	34	view →
LAML	DFS	Tertile	All	0.446	0.617	.013	32	view →
THCA	OS	Quartile	All	0.955	0.998	<.001	28	view →
CHOL	DFS	Median	All	0.712	0.159	<.001	20	view →
STAD	OS	Tertile	All	0.307	0.510	.010	20	view →
PCPG	DFS	Tertile	All	0.597	0.845	<.001	18	view →
COAD	DFS	Tertile	II,III,IV	0.273	0.517	.010	13	view →
SARC	DFS	Quartile	All	0.397	0.703	<.001	11	view →
THYM	DFS	Median	II,III,IV	0.594	0.872	.016	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MYH1–ACC (OS)

Open the ACC breakdown →