MYCN

Across TCGA patient cohorts, MYCN mutation is significantly associated with the RNA expression of many other genes, with 970 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYCN-associated genes across cancer lineages are RN7SL97P, MIR8076, and RNU6-1055P. Each is linked with MYCN in more than 2 cancer types. Because this analysis shows association rather than direction, both MYCN-to-partner and partner-to-MYCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL97P grouped by MYCN-low versus MYCN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYCN→partner) and Y-score (partner→MYCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL97P →	+0.120	+4.144	<.001	.009	3	3
SKCM	MIR8076 →	+0.155	+2.851	<.001	.003	3	3
LUSC	RNU6-1055P →	+0.790	+3.781	<.001	.007	3	2
LIHC	RN7SL267P →	+0.201	+6.149	<.001	.002	3	2
COAD	MIR3126 →	+0.614	+4.225	<.001	.007	3	2
LIHC	RNU7-11P →	+0.632	+5.355	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 970 associations by consensus.

RN7SL97P by MYCN expression — CESC

Explore this box plot interactively →