MYC

Across TCGA patient cohorts, MYC mutation is significantly associated with the RNA expression of many other genes, with 1,475 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYC-associated genes across cancer lineages are TRIM51HP, RNU6-222P, and LINC02658. Each is linked with MYC in more than 1 cancer types. Because this analysis shows association rather than direction, both MYC-to-partner and partner-to-MYC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM51HP grouped by MYC-low versus MYC-high in DLBC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYC→partner) and Y-score (partner→MYC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	TRIM51HP →	+0.168	+4.357	.001	.004	3	2
DLBC	RNU6-222P →	+0.937	+4.099	<.001	.008	3	2
DLBC	LINC02658 →	+0.283	+4.357	<.001	.004	3	2
DLBC	RN7SL183P →	+0.427	+4.357	.001	.004	3	2
COAD	SNORD114-23 →	+0.689	+4.917	<.001	.003	3	2
COAD	RNU6-1020P →	+0.780	+4.435	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,475 associations by consensus.

TRIM51HP by MYC expression — DLBC

Explore this box plot interactively →