MYBPH

Across TCGA patient cohorts, MYBPH mutation is significantly associated with the RNA expression of many other genes, with 864 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYBPH-associated genes across cancer lineages are CXCL13, ACBD4, and NR2C2AP. Each is linked with MYBPH in more than 1 cancer types. Because this analysis shows association rather than direction, both MYBPH-to-partner and partner-to-MYBPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXCL13 grouped by MYBPH-low versus MYBPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPH→partner) and Y-score (partner→MYBPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCL13 →	+1.843	+2.700	<.001	.005	3	2
UCEC	ACBD4 →	+0.375	+3.202	.009	.009	3	2
UCEC	NR2C2AP →	+0.410	+2.708	.005	.003	3	2
SKCM	BTBD6 →	+0.551	+3.706	.003	<.001	3	2
UCEC	RNA5SP86 →	+0.405	+2.621	<.001	.002	3	2
UCEC	LINC02099 →	+0.062	+2.627	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 864 associations by consensus.

CXCL13 by MYBPH expression — UCEC

Explore this box plot interactively →