MYBPH

Across TCGA cell cohorts, MYBPH mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MYBPH-associated genes across cancer lineages are FAM71B, FSHB, and NPVF. Each is linked with MYBPH in more than 1 cancer types. Because this analysis shows association rather than direction, both MYBPH-to-partner and partner-to-MYBPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71B grouped by MYBPH-low versus MYBPH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPH→partner) and Y-score (partner→MYBPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM71B →	+0.029	+5.060	<.001	.001	3	2
PANCREAS	FSHB →	+0.035	+4.614	<.001	.004	3	1
BONE	NPVF →	+0.053	+4.672	<.001	.001	3	1
BONE	UGT2B10 →	+0.010	+4.169	<.001	.008	3	1
BONE	ACTRT1 →	+0.010	+4.169	<.001	.008	3	1
BONE	SSTR4 →	+0.015	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

FAM71B by MYBPH expression — BLOOD_Leukemia

Explore this box plot interactively →