MYBPC2

Across TCGA patient cohorts, MYBPC2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYBPC2-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and P-Cadherin. Each is linked with MYBPC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MYBPC2-to-partner and partner-to-MYBPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MYBPC2-low versus MYBPC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPC2→partner) and Y-score (partner→MYBPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.332	+4.247	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.603	+2.584	<.001	<.001	3	3
SKCM	P-Cadherin →	-0.209	-2.321	.010	.032	3	3
UCEC	Ku80 →	+0.288	+1.598	<.001	<.001	3	3
UCEC	VHL →	-0.885	-1.947	<.001	<.001	3	3
UCEC	ATM →	-0.439	-2.156	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1 by MYBPC2 expression — UCEC

Explore this box plot interactively →