MYBPC2

Across TCGA pan-cancer cohorts, MYBPC2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MYBPC2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MYBPC2 RNA is repressed in tumor relative to normal tissue. In most cancer types MYBPC2 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where MYBPC2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYBPC2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.392	.001	6	view →
HNSC	Male	IV	−3.788	.012	5	view →
LUAD	Female	All	+0.659	<.001	5	view →
KICH	All	II,III,IV	−0.248	.016	5	view →
UCEC	All	II,III,IV	+0.829	.038	4	view →
KIRP	Male	All	+0.696	.005	4	view →
KIRC	All	All	+0.285	.001	4	view →
LIHC	All	All	+0.048	.011	4	view →
LUSC	All	All	+0.451	.013	2	view →
BLCA	All	All	+0.353	.032	2	view →
CHOL	All	All	+0.534	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MYBPC2–COAD

Open the COAD breakdown →