MYBPC2

Across TCGA cell cohorts, MYBPC2 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYBPC2-associated genes across cancer lineages are KAAG1, ODF1, and ADH1B. Each is linked with MYBPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYBPC2-to-partner and partner-to-MYBPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KAAG1 grouped by MYBPC2-low versus MYBPC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPC2→partner) and Y-score (partner→MYBPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KAAG1 →	+0.075	+4.440	<.001	<.001	3	2
BLOOD_Leukemia	ODF1 →	+0.074	+3.266	<.001	.003	3	2
BLOOD_Leukemia	ADH1B →	+0.025	+3.772	<.001	<.001	3	2
BLOOD_Leukemia	TMEM178B →	+0.518	+3.409	<.001	.008	3	2
LARGE_INTESTINE	BEST3 →	+0.448	+3.169	<.001	.006	3	2
LARGE_INTESTINE	BTNL2 →	+0.026	+2.540	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

KAAG1 by MYBPC2 expression — BLOOD_Leukemia

Explore this box plot interactively →