MYBPC2

Across TCGA cell cohorts, MYBPC2 mutation is significantly associated with the mutation status of many other genes, with 3,614 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MYBPC2-associated genes across cancer lineages are RIMBP2, PTPRB, and ARHGAP30. Each is linked with MYBPC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYBPC2-to-partner and partner-to-MYBPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIMBP2 grouped by MYBPC2-low versus MYBPC2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBPC2→partner) and Y-score (partner→MYBPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIMBP2 →	+2.347	+2.584	.004	.004	1	6
UPPER_AERODIGESTIVE_TRACT	PTPRB →	+4.539	+5.193	<.001	<.001	1	6
OVARY	ARHGAP30 →	+4.217	+4.217	.001	.001	1	6
URINARY_TRACT	SYNJ1 →	+4.672	+4.672	.001	.001	1	5
BLOOD_Lymphoma	NFATC1 →	+3.523	+3.523	.001	.001	1	5
BLOOD_Leukemia	PCDH10 →	+4.084	+3.582	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,614 associations by consensus.

RIMBP2 by MYBPC2 expression — BLOOD_Leukemia

Explore this box plot interactively →