MYBBP1A

Across TCGA cell cohorts, MYBBP1A mutation is significantly associated with the RNA expression of many other genes, with 984 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYBBP1A-associated genes across cancer lineages are COPS3, DEFB108B, and RTRAF. Each is linked with MYBBP1A in more than 1 cancer types. Because this analysis shows association rather than direction, both MYBBP1A-to-partner and partner-to-MYBBP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS3 grouped by MYBBP1A-low versus MYBBP1A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYBBP1A→partner) and Y-score (partner→MYBBP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	COPS3 →	+0.606	+3.614	.002	<.001	3	2
BLOOD_Leukemia	DEFB108B →	+0.051	+2.514	.009	.005	3	2
LARGE_INTESTINE	RTRAF →	+0.403	+3.169	.001	.006	3	2
LUNG_NSCLC_LUAD	WFDC6 →	+0.057	+4.887	<.001	.009	3	2
BLOOD_Lymphoma	ZC2HC1B →	+0.168	+3.736	<.001	.009	3	2
BLOOD_Lymphoma	MMP27 →	+0.017	+4.794	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 984 associations by consensus.

COPS3 by MYBBP1A expression — BLOOD_Leukemia

Explore this box plot interactively →