MYBBP1A

Across TCGA pan-cancer cohorts, MYBBP1A RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MYBBP1A data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MYBBP1A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MYBBP1A expression acts as an unfavorable survival marker, although some lineages such as SCLC and READ show a favorable association.

ACC, KIRP, and SCLC are the cancer types where MYBBP1A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.329	0.811	<.001	75	view →
KIRP	OS	Quartile	III,IV	0.217	0.666	.004	45	view →
SCLC	OS	Tertile	All	0.744	0.338	<.001	45	view →
KICH	OS	Tertile	All	0.628	1.000	.006	39	view →
LGG	DFS	Tertile	All	0.658	0.826	<.001	39	view →
THCA	DFS	Tertile	IV	0.565	0.944	.002	37	view →
LUAD	DFS	Tertile	III,IV	0.179	0.701	<.001	35	view →
MESO	DFS	Median	IV	0.186	0.524	.004	33	view →
READ	OS	Quartile	III,IV	1.000	0.738	.007	31	view →
LIHC	OS	Median	All	0.390	0.649	.002	28	view →
LUSC	DFS	Median	III,IV	0.526	0.914	.011	21	view →
HNSC	OS	Quartile	All	0.632	0.880	.004	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MYBBP1A–ACC (DFS)

Open the ACC breakdown →