MYB

Across TCGA patient cohorts, MYB mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYB-associated genes across cancer lineages are Tuberin, eIF4E, and Notch1. Each is linked with MYB in more than 1 cancer types. Because this analysis shows association rather than direction, both MYB-to-partner and partner-to-MYB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by MYB-low versus MYB-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYB→partner) and Y-score (partner→MYB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Tuberin →	+0.333	+2.331	.020	.019	3	2
UCEC	eIF4E →	+0.199	+3.335	.007	.005	3	2
UCEC	Notch1 →	+0.267	+2.392	<.001	<.001	3	2
UCEC	AR →	-0.283	-1.362	.032	.037	3	2
UCEC	eIF4G →	+0.295	+1.662	.007	.011	3	1
UCEC	FASN →	+0.280	+1.362	.044	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Tuberin by MYB expression — LUSC

Explore this box plot interactively →