MYB

Across TCGA cell cohorts, MYB mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MYB-associated genes across cancer lineages are ZNRF4, OR56A5, and MYH4. Each is linked with MYB in more than 1 cancer types. Because this analysis shows association rather than direction, both MYB-to-partner and partner-to-MYB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNRF4 grouped by MYB-low versus MYB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYB→partner) and Y-score (partner→MYB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNRF4 →	+0.004	+4.437	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	OR56A5 →	+0.045	+4.736	<.001	.009	3	2
BLOOD_Leukemia	MYH4 →	+0.004	+4.969	<.001	.003	3	2
LARGE_INTESTINE	C20orf173 →	+0.028	+3.684	<.001	.006	3	1
BLOOD_Leukemia	WFDC11 →	+0.030	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SMIM23 →	+0.022	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

ZNRF4 by MYB expression — LARGE_INTESTINE

Explore this box plot interactively →