MYB-AS1

Across TCGA pan-cancer cohorts, MYB-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MYB-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MYB-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYB-AS1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

BLCA, BRCA, and STAD are the cancer types where MYB-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYB-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.125	.013	7	view →
BRCA	All	II,III,IV	+0.397	<.001	6	view →
STAD	All	All	+0.268	.001	5	view →
COAD	All	II,III,IV	+0.222	.011	4	view →
HNSC	Female	II,III,IV	−0.056	.039	2	view →
THCA	All	III,IV	+0.041	.038	2	view →
LUSC	All	All	+0.167	.019	1	view →
HNSC	Male	All	+0.036	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

MYB-AS1–BLCA

Open the BLCA breakdown →