MXRA8

Across TCGA pan-cancer cohorts, MXRA8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MXRA8 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MXRA8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MXRA8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, GBM, and PDAC are the cancer types where MXRA8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.470	0.841	.016	8	view →
GBM	OS	Tertile	All	0.253	0.499	.012	6	view →
PDAC	OS	Quartile	All	0.257	0.578	.021	5	view →
CCRCC	OS	Median	IV	1.000	0.181	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MXRA8–LSCC (DFS)

Open the LSCC breakdown →