MXRA8

Across TCGA patient cohorts, MXRA8 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MXRA8-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1_pT37_T46, and MEK1. Each is linked with MXRA8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MXRA8-to-partner and partner-to-MXRA8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by MXRA8-low versus MXRA8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXRA8→partner) and Y-score (partner→MXRA8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.499	+2.817	.007	.036	2	1
UCEC	4E-BP1_pT37_T46 →	-0.775	-3.000	<.001	.037	2	1
UCEC	MEK1 →	+0.513	+3.000	.015	.037	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p62 Lck ligand by MXRA8 expression — UCEC

Explore this box plot interactively →