MXRA5Y

Across TCGA pan-cancer cohorts, MXRA5Y RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MXRA5Y data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MXRA5Y RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MXRA5Y expression acts as an unfavorable survival marker, although some lineages such as LUAD and OV show a favorable association.

ACC, GBM, and MESO are the cancer types where MXRA5Y RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.240	0.636	<.001	56	view →
GBM	DFS	Quartile	All	0.153	0.322	<.001	36	view →
MESO	DFS	Quartile	All	0.244	0.482	.002	29	view →
UVM	DFS	Quartile	All	0.500	0.889	.014	28	view →
LUAD	DFS	Median	III,IV	0.572	0.247	.007	25	view →
OV	DFS	Median	II,III,IV	0.422	0.340	.006	24	view →
THCA	OS	Tertile	All	0.927	1.000	.009	22	view →
BLCA	DFS	Tertile	III,IV	0.489	0.607	.018	16	view →
PAAD	OS	Tertile	All	0.250	0.569	.001	15	view →
SKCM	OS	Median	II,III,IV	0.463	0.231	.004	14	view →
LGG	DFS	Tertile	All	0.707	0.856	.002	12	view →
STAD	DFS	Median	All	0.324	0.483	.027	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MXRA5Y–ACC (DFS)

Open the ACC breakdown →