MXRA5Y

Across TCGA pan-cancer cohorts, MXRA5Y RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MXRA5Y’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MXRA5Y RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MXRA5Y is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, LUAD, and KICH are the cancer types where MXRA5Y tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MXRA5Y RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.385	<.001	9	view →
LUAD	All	II,III,IV	+0.521	<.001	8	view →
KICH	Male	All	−0.290	<.001	7	view →
BRCA	All	III,IV	+0.643	<.001	6	view →
LUSC	All	II,III,IV	+0.799	<.001	5	view →
STAD	All	All	+0.662	.003	4	view →
COAD	Female	All	+0.249	<.001	4	view →
KIRC	Female	All	−0.239	.006	3	view →
THCA	Male	All	+0.357	.037	2	view →
LIHC	Male	III,IV	−0.036	.023	2	view →
BLCA	All	III,IV	+0.279	.045	1	view →
KIRP	All	All	−0.118	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MXRA5Y–HNSC

Open the HNSC breakdown →