MXRA5

Across TCGA pan-cancer cohorts, MXRA5 Mutation is linked to patient survival in 15 of 34 cancer types, making it a survival-associated MXRA5 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher MXRA5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MXRA5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

LUSC, HNSC, and KIRC are the cancer types where MXRA5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.331	0.627	.003	24	view →
HNSC	DFS	Median	III,IV	0.139	0.598	<.001	20	view →
KIRC	DFS	Median	IV	0.054	0.632	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
LUAD	OS	Median	II,III,IV	0.461	0.708	.005	11	view →
UCEC	DFS	Median	All	0.883	0.611	.021	8	view →
THCA	DFS	Median	II,III,IV	0.103	0.928	<.001	6	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	6	view →
GBM	DFS	Median	All	0.053	0.249	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.172	0.621	.002	6	view →
LGG	DFS	Median	All	0.601	0.836	.015	3	view →
SARC	OS	Median	All	0.114	0.490	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

MXRA5–LUSC (OS)

Open the LUSC breakdown →