MXRA5

Across TCGA pan-cancer cohorts, MXRA5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MXRA5 data layer compared with 24 for mass-spec protein and 15 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MXRA5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MXRA5 expression acts as an unfavorable survival marker.

LSCC, CCRCC, and COAD are the cancer types where MXRA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.495	0.869	.004	29	view →
CCRCC	DFS	Median	II,III,IV	0.128	0.952	.003	28	view →
COAD	DFS	Quartile	III,IV	0.683	1.000	.027	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	11	view →
LUAD	OS	Tertile	III,IV	0.449	0.848	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MXRA5–LSCC (DFS)

Open the LSCC breakdown →