Across TCGA patient cohorts, MXD3 mutation is significantly associated with the RNA expression of many other genes, with 705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MXD3-associated genes across cancer lineages are FKBP1AP3, RNU6-668P, and PPIAP37. Each is linked with MXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MXD3-to-partner and partner-to-MXD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MXD3→partner) and Y-score (partner→MXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FKBP1AP3 →	+0.414	+3.799	<.001	.002	3	2
UCEC	RNU6-668P →	+0.212	+3.186	<.001	.001	3	2
UCEC	PPIAP37 →	+0.105	+2.113	.004	.004	3	2
UCEC	RANP5 →	+0.171	+2.027	.001	.004	3	2
SKCM	RN7SL74P →	+0.129	+4.867	<.001	.005	3	2
SKCM	EIF2S2P7 →	+0.032	+4.513	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 705 associations by consensus.

Exploration

MXD3 survival (RNA) · tumor vs normal (RNA) · all MXD3 data types