MX1

Across TCGA pan-cancer cohorts, MX1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MX1 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MX1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where MX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.829	0.609	.033	11	view →
CCRCC	OS	Quartile	All	0.744	0.925	.039	5	view →
LSCC	OS	Median	II,III,IV	0.600	0.870	.012	3	view →
PDAC	OS	Median	IV	0.395	0.937	.026	3	view →
GBM	OS	Median	All	0.955	0.761	.029	1	view →
LUAD	DFS	Median	All	0.513	0.843	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MX1–HNSC (OS)

Open the HNSC breakdown →