MX1

Across TCGA pan-cancer cohorts, MX1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MX1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MX1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KICH, and BRCA are the cancer types where MX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+1.182	<.001	11	view →
KICH	All	II,III,IV	−1.069	<.001	6	view →
BRCA	All	All	+1.021	<.001	6	view →
BLCA	All	III,IV	+0.957	.015	6	view →
STAD	All	All	+0.649	.027	3	view →
KIRC	All	All	+0.423	.001	3	view →
ESCA	All	II,III,IV	+1.964	.032	2	view →
CHOL	All	All	+1.798	.002	2	view →
KIRP	Female	All	−0.670	.034	2	view →
PRAD	All	All	−0.586	<.001	2	view →
COAD	Male	II,III,IV	+0.844	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MX1–HNSC

Open the HNSC breakdown →