MX1

Across TCGA cell cohorts, MX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,592 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MX1-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Positive regulation of canonical NF-kappaB signal transduction, and Negative regulation of viral genome replication. Each is linked with MX1 in more than 18 cancer types. Because this analysis shows association rather than direction, both MX1-to-partner and partner-to-MX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by MX1-low versus MX1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MX1→partner) and Y-score (partner→MX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytoplasmic pattern recognition receptor signaling pathway →	+0.092	+2.150	<.001	<.001	3	19
LIVER	Positive regulation of canonical NF-kappaB signal transduction →	+0.080	+2.078	.003	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral genome replication →	+0.209	+3.376	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.130	+2.881	<.001	<.001	3	17
KIDNEY	Defense response to virus →	+0.107	+4.348	.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of viral process →	+0.184	+3.202	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,592 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by MX1 expression — LUNG_SCLC

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