MVK

Across TCGA pan-cancer cohorts, MVK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MVK data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MVK mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MVK expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where MVK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.989	0.133	.020	20	view →
COAD	DFS	Median	All	1.000	0.888	.023	18	view →
PDAC	OS	Tertile	III,IV	0.876	0.381	.012	10	view →
LUAD	OS	Median	II,III,IV	1.000	0.433	.005	10	view →
GBM	DFS	Quartile	All	0.250	0.522	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MVK–CCRCC (OS)

Open the CCRCC breakdown →