MVK

Across TCGA pan-cancer cohorts, MVK RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MVK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MVK RNA is repressed in tumor relative to normal tissue. In most cancer types MVK is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, BLCA, and COAD are the cancer types where MVK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MVK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.521	<.001	11	view →
BLCA	Male	All	+1.193	<.001	11	view →
COAD	Female	All	+0.644	<.001	10	view →
UCEC	All	All	+0.539	<.001	6	view →
LUAD	Female	All	−0.409	<.001	6	view →
THCA	All	III,IV	−0.319	.006	3	view →
STAD	Male	IV	+0.835	.005	2	view →
BRCA	All	IV	+0.445	.001	2	view →
LUSC	All	All	+0.234	.014	2	view →
LIHC	All	III,IV	+0.529	.048	1	view →
KIRP	All	II,III,IV	+0.513	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MVK–KICH

Open the KICH breakdown →