MVK

Across TCGA patient cohorts, MVK mutation is significantly associated with the RNA expression of many other genes, with 1,092 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MVK-associated genes across cancer lineages are TYMS, LINC01881, and CCDC58P1. Each is linked with MVK in more than 2 cancer types. Because this analysis shows association rather than direction, both MVK-to-partner and partner-to-MVK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYMS grouped by MVK-low versus MVK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVK→partner) and Y-score (partner→MVK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYMS →	+0.895	+3.329	.003	.005	3	3
UCEC	LINC01881 →	+0.377	+2.700	.007	.006	3	3
SKCM	CCDC58P1 →	+0.117	+4.391	.006	<.001	3	3
UCEC	MTMR12 →	+0.600	+2.700	.007	.006	3	2
UCEC	SAR1B →	+0.562	+3.483	<.001	.002	3	2
UCEC	SFXN1 →	+0.603	+3.395	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,092 associations by consensus.

TYMS by MVK expression — UCEC

Explore this box plot interactively →