MVK

Across TCGA patient cohorts, MVK mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MVK-associated genes across cancer lineages are c-Kit, EGFR_pY1068, and GATA6. Each is linked with MVK in more than 1 cancer types. Because this analysis shows association rather than direction, both MVK-to-partner and partner-to-MVK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by MVK-low versus MVK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVK→partner) and Y-score (partner→MVK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.252	-3.321	.039	.010	3	2
UCEC	EGFR_pY1068 →	-0.309	-3.169	.019	.019	3	1
UCEC	GATA6 →	-0.170	-3.314	.036	.010	3	1
UCEC	MEK1 →	+0.563	+3.169	.003	.019	3	1
UCEC	mTOR_pS2448 →	-0.232	-3.321	.003	.010	3	1
UCEC	PEA-15_pS116 →	+0.492	+3.321	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

c-Kit by MVK expression — UCEC

Explore this box plot interactively →