MVK

Across TCGA cell cohorts, MVK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,458 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible MVK-associated GO terms across cancer lineages are Farnesyl diphosphate biosynthetic process, mevalonate pathway, Isoprenoid biosynthetic process via mevalonate, and Isopentenyl diphosphate biosynthetic process, mevalonate pathway. Each is linked with MVK in more than 19 cancer types. Because this analysis shows association rather than direction, both MVK-to-partner and partner-to-MVK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Farnesyl diphosphate biosynthetic process, mevalonate pathway grouped by MVK-low versus MVK-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MVK→partner) and Y-score (partner→MVK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Farnesyl diphosphate biosynthetic process, mevalonate pathway →	+0.292	+1.518	<.001	<.001	3	20
OESOPHAGUS	Isoprenoid biosynthetic process via mevalonate →	+0.292	+1.518	<.001	<.001	3	20
URINARY_TRACT	Isopentenyl diphosphate biosynthetic process, mevalonate pathway →	+0.244	+1.545	<.001	<.001	3	20
BONE	Cholesterol biosynthetic process via desmosterol →	+0.255	+1.109	<.001	<.001	3	20
BONE	Zymosterol metabolic process →	+0.275	+1.109	<.001	<.001	3	20
BONE	Zymosterol biosynthetic process →	+0.275	+1.109	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,458 associations by consensus.

Farnesyl diphosphate biosynthetic process, mevalonate pathway by MVK expression — OESOPHAGUS

Explore this box plot interactively →