MVK

Across TCGA cell cohorts, MVK mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MVK-associated genes across cancer lineages are EPPIN, NKX2-6, and OR52E4. Each is linked with MVK in more than 1 cancer types. Because this analysis shows association rather than direction, both MVK-to-partner and partner-to-MVK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPPIN grouped by MVK-low versus MVK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVK→partner) and Y-score (partner→MVK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR1D4 →	+0.062	+5.539	<.001	.003	3	1
LARGE_INTESTINE	MT4 →	+1.898	+3.374	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EPPIN by MVK expression — BLOOD_Leukemia

Explore this box plot interactively →