MVD

Across TCGA patient cohorts, MVD RNA expression is significantly associated with the mutation status of many other genes, with 11,257 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MVD-associated genes across cancer lineages are TP53, TTN, and PIK3CA. Each is linked with MVD in more than 5 cancer types. Because this analysis shows association rather than direction, both MVD-to-partner and partner-to-MVD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by MVD-low versus MVD-high in SKCM.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVD→partner) and Y-score (partner→MVD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TP53 →	+2.108	+0.273	<.001	.009	3	6
UCEC	TTN →	+1.021	+0.505	<.001	<.001	3	5
STAD	PIK3CA →	+1.584	+0.375	.002	.001	3	4
HNSC	SSPOP →	+2.505	+0.524	.009	.001	3	4
STAD	ZNF536 →	+3.807	+0.330	<.001	.007	3	4
STAD	TIE1 →	+2.321	+0.529	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,257 associations by consensus.

TP53 by MVD expression — SKCM

Explore this box plot interactively →