MVD

Across TCGA pan-cancer cohorts, MVD RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MVD data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MVD RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MVD expression acts as an unfavorable survival marker, although some lineages such as UVM and UCEC show a favorable association.

UVM, ACC, and LIHC are the cancer types where MVD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.891	0.512	.001	80	view →
ACC	DFS	Tertile	All	0.220	0.716	<.001	68	view →
LIHC	DFS	Quartile	II,III,IV	0.273	0.576	<.001	59	view →
UCEC	DFS	Quartile	All	0.830	0.551	.006	44	view →
HNSC	DFS	Tertile	III,IV	0.169	0.406	.003	37	view →
BLCA	OS	Quartile	All	0.478	0.819	.003	35	view →
LAML	DFS	Tertile	All	0.292	0.546	<.001	30	view →
LUAD	OS	Quartile	All	0.678	0.881	.004	27	view →
SARC	OS	Median	All	0.786	0.885	.001	25	view →
SCLC	OS	Tertile	All	0.858	0.597	.010	24	view →
THYM	OS	Quartile	II,III,IV	1.000	0.809	.010	20	view →
GBM	DFS	Tertile	All	0.439	0.208	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MVD–UVM (DFS)

Open the UVM breakdown →