MVD

Across TCGA cell cohorts, MVD mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MVD-associated genes across cancer lineages are BPIFB6, ADH1A, and GPR119. Each is linked with MVD in more than 1 cancer types. Because this analysis shows association rather than direction, both MVD-to-partner and partner-to-MVD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by MVD-low versus MVD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MVD→partner) and Y-score (partner→MVD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ADH1A →	+0.169	+3.920	<.001	.005	3	1
BLOOD_Lymphoma	GPR119 →	+0.022	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	ZSWIM2 →	+0.035	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	NEUROG1 →	+0.006	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OTOL1 →	+0.012	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

BPIFB6 by MVD expression — LARGE_INTESTINE

Explore this box plot interactively →