MUTYH

Across TCGA patient cohorts, MUTYH protein abundance is significantly associated with the RNA expression of many other genes, with 5,436 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MUTYH-associated genes across cancer lineages are C10orf88B, FAM72B, and RRNAD1. Each is linked with MUTYH in more than 2 cancer types. Because this analysis shows association rather than direction, both MUTYH-to-partner and partner-to-MUTYH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MUTYH versus C10orf88B in LSCC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUTYH→partner) and Y-score (partner→MUTYH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	C10orf88B →	+1.037	+0.624	<.001	.001	3	3
UCEC	FAM72B →	+0.819	+0.487	.001	.003	3	3
LSCC	RRNAD1 →	+0.512	+0.543	.004	.001	3	2
LUAD	H2BC4 →	+0.754	+0.468	<.001	.007	3	2
LSCC	FRAT2 →	+0.741	+0.549	<.001	.005	3	2
LUAD	ARSL →	-1.616	-0.536	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,436 associations by consensus.

MUTYH vs C10orf88B — LSCC

Explore this scatter interactively →