MUSK

Across TCGA patient cohorts, MUSK mutation is significantly associated with the RNA expression of many other genes, with 3,443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MUSK-associated genes across cancer lineages are GOT1, HDHD5, and COX15. Each is linked with MUSK in more than 2 cancer types. Because this analysis shows association rather than direction, both MUSK-to-partner and partner-to-MUSK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by MUSK-low versus MUSK-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MUSK→partner) and Y-score (partner→MUSK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GOT1 →	+0.403	+2.175	<.001	<.001	3	3
SKCM	HDHD5 →	+0.286	+1.478	.004	.006	3	3
UCEC	COX15 →	+0.281	+1.540	.004	.001	3	3
UCEC	FAM177A1 →	+0.286	+1.601	.001	.002	3	3
UCEC	MRPL39 →	+0.349	+1.551	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.467	+1.572	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,443 associations by consensus.

GOT1 by MUSK expression — SKCM

Explore this box plot interactively →