MUSK

Across TCGA pan-cancer cohorts, MUSK RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MUSK data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MUSK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MUSK expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

KIRC, LGG, and LUAD are the cancer types where MUSK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.545	0.733	<.001	90	view →
LGG	OS	Median	All	0.356	0.523	<.001	53	view →
LUAD	DFS	Tertile	All	0.754	0.609	<.001	37	view →
THCA	DFS	Tertile	II,III,IV	0.842	0.936	.004	26	view →
UCS	DFS	Quartile	II,III,IV	0.690	0.171	.005	24	view →
SKCM	OS	Tertile	All	0.396	0.222	.001	20	view →
HNSC	OS	Quartile	II,III,IV	0.597	0.770	.008	20	view →
MESO	DFS	Median	All	0.461	0.311	.014	18	view →
KIRP	DFS	Median	II,III,IV	0.510	1.000	.003	16	view →
ESCA	DFS	Tertile	II,III,IV	0.614	0.404	.023	12	view →
CESC	OS	Quartile	IV	0.956	0.379	.040	12	view →
BLCA	DFS	Tertile	III,IV	0.620	0.358	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MUSK–KIRC (OS)

Open the KIRC breakdown →