MUSK

Across TCGA cell cohorts, MUSK RNA expression is significantly associated with the go_rna of many other GO terms, with 982 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MUSK-associated GO terms across cancer lineages are Arp2/3 complex-mediated actin nucleation, Response to rapamycin, and Negative regulation of cilium assembly. Each is linked with MUSK in more than 4 cancer types. Because this analysis shows association rather than direction, both MUSK-to-partner and partner-to-MUSK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Arp2/3 complex-mediated actin nucleation grouped by MUSK-low versus MUSK-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MUSK→partner) and Y-score (partner→MUSK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Arp2/3 complex-mediated actin nucleation →	+0.064	+0.143	.004	.005	3	5
UPPER_AERODIGESTIVE_TRACT	Response to rapamycin →	+0.085	+0.067	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cilium assembly →	+0.056	+0.072	<.001	.001	3	4
PANCREAS	Regulation of cell communication by electrical coupling involved in cardiac conduction →	+0.103	+0.061	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of epidermal growth factor-activated receptor activity →	+0.071	+0.063	<.001	.005	3	4
LUNG_NSCLC_LUSC	Negative regulation of plasma membrane bounded cell projection assembly →	+0.047	+0.144	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 982 associations by consensus.

Arp2/3 complex-mediated actin nucleation by MUSK expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →