MUC7

Across TCGA patient cohorts, MUC7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,780 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MUC7-associated GO terms across cancer lineages are Phosphatidylinositol 3-kinase/protein kinase B signal transduction, Positive regulation of growth, and Regulation of cell-substrate junction organization. Each is linked with MUC7 in more than 6 cancer types. Because this analysis shows association rather than direction, both MUC7-to-partner and partner-to-MUC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol 3-kinase/protein kinase B signal transduction grouped by MUC7-low versus MUC7-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MUC7→partner) and Y-score (partner→MUC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.022	+0.028	<.001	<.001	3	7
TGCT	Positive regulation of growth →	+0.027	+0.035	<.001	<.001	3	7
TGCT	Regulation of cell-substrate junction organization →	+0.064	+0.031	<.001	<.001	3	7
TGCT	Negative regulation of lens fiber cell differentiation →	+0.091	+0.024	<.001	<.001	3	7
GBM	Regulation of receptor-mediated endocytosis →	+0.018	+0.009	.001	.001	3	7
TGCT	Negative regulation of lipoprotein metabolic process →	+0.076	+0.039	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,780 associations by consensus.

Phosphatidylinositol 3-kinase/protein kinase B signal transduction by MUC7 expression — TGCT

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